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Tuesday, September 11, 2007
Link between obesity and infertility proven

 

 

 

SCIENTISTS have proven the link between obesity and infertility, with tests showing fat mice are more likely to have damaged embryos which do not become babies.

Obesity has long been linked to pregnancy complications and higher rates of miscarriage and now Australian researchers have proof extra body fat may cause problems in moments after conception.

Monash University scientists will present evidence at a national fertility conference today showing obesity, independent of age, can damage a woman's embryos and stop them developing.

While the connection was suspected, research failed to show a clear link.

Dr Gayle Jones, senior research fellow at Monash Immunology and Stem Cell Laboratories, compared lean and fat mice in conception, watching egg fertilisation through to implantation of the embryo in the uterus.

"We found fat mice compared to the lean mice had a significantly reduced ability to undergo complete embryo development in vitro," Dr Jones said.

Either way, they say the results are significant as they help explain why obese women have difficulty conceiving.

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Child obesity growing problem in Colorado

 

 

 

Low-income, minority groups particularly at risk.

By JOHN NORTON
THE PUEBLO CHIEFTAIN

Not everyone in the traditionally healthy state of Colorado is out there riding mountain bikes, hiking or engaging in other sports, especially not its youngest residents.

The Colorado Children's Campaign issued a warning this month that childhood obesity is as much a problem here as in other U.S. states, threatening to cause later health problems such as diabetes, heart and liver disease and high blood pressure.

The problem is especially threatening to youngsters from low-income families and minorities who have a genetic inclination toward heart disease and diabetes.

The report claims that in Colorado, Hispanic children between the ages of 2 and 14 are almost three times as likely as white children to be overweight, and children living in poverty are three times as likely to be overweight as those in higher-income families.

It blames sedentary lifestyles of more television watching and less exercise in neighborhoods with limited recreational opportunities, coupled with higher exposure to advertisements for high-fat and high-sugar foods.

The report also zeroes in on increased soda consumption and larger portion sizes.

Along with health problems individuals face, the CCC said there are big economic costs to the state. Obesity-related medical expenditures in Colorado are estimated at $874 million annually. From the three-year period of 1979-1981 to the three-year period 1997-1999, hospital costs of treating children for obesity-related ailments have more than tripled.

To deal with the problem, the campaign supports the wellness policies mandated for school districts that take part in the federal school lunch program and urges more after-school programs.

Parent involvement is another crucial issue, it said, pointing out that parents are the best examples for healthy eating and exercise habits.

Communities also should make a greater effort to provide recreational facilities.

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Elevated Blood Pressure In Youth Linked To Rise In Childhood Obesity

 

 

 

Science Daily A Morehouse School of Medicine (MSM) researcher is the lead author of a new study that finds that after decades of decline, blood pressure (HBP) levels in children and adolescents are increasing.

"General obesity, called 'overweight' in childhood, increased over time in all racial and ethnic groups," said Rebecca Din-Dzietham, M.D., M.P.H., Ph.D., lead author of the study and associate professor of community health and preventive medicine at MSM in Atlanta, Ga. "The prevalence of childhood obesity drifted slightly and steadily higher after the 1963 survey and increased significantly during the 1976-1980 survey period with a sharp rise after that time."

Din-Dzietham said that each one centimeter increase in waist circumference raised the likelihood of high blood pressure by 10 percent and the likelihood of pre-high blood pressure by five percent.

The study is based on an analysis of national health surveys between 1963 and 2002 published in Circulation: Journal of the American Heart Association.

Researchers analyzed data from seven U.S. government surveys conducted in children and adolescents ages eight to 17 between 1963 and 2002. They examined trends in the age-adjusted prevalence of high blood pressure and pre-high blood pressure in boys and girls. They also looked at trends in various racial/ethnic groups and the impact of increasing obesity on those trends. Some of the government surveys included children younger than eight, but their data were removed from the analysis.

Normal blood pressure was defined as having both systolic pressure (the upper number representing the pressure when the heart contracts, or beats) and diastolic pressure (the lower number representing the pressure when the heart relaxes between beats) below the 90th percentile. Pre-HBP was defined as either a systolic or diastolic blood pressure above the 90th percentile but below the 95th percentile or having blood pressure levels above 120/80 mm Hg, but below 95th percentile. HBP was defined as either systolic or diastolic blood pressure at or above the 95th percentile.

The prevalence of HBP and pre-HBP in children and adolescents showed a downward trend between 1963 and the 1988-1994 survey. But the trend began to reverse through 2002. For example, the prevalence of high blood pressure in all children and adolescents decreased from 11.1 percent in the 1976-1980 (Black and white) and 4.7 percent in 1982-1984 survey (first national survey for Mexican-American youth) to 2.7 percent in the 1988-1994 survey (all children), but rose to 3.7 percent in the 1999-2002 survey (all children).

The change was even more pronounced among Mexican-American males. For them, the prevalence of high blood pressure dropped from 6.1 percent in 1982-1984 to 3.1 percent in 1988-94 before rising to 5.3 percent in 1999-2002, making of them the subgroup with the largest and significant rise, 2.2 percent, in high blood pressure prevalence.

Pre-high blood pressure is relevant because the long-running Bogalusa (La.) Heart Study found that children whose blood pressure was chronically at or above the 90th percentile showed signs of early organ damage as young adults, such as greater thickening of the heart wall or higher amounts of a protein called albumin in the urine.

Autopsies on adolescents and young adults who were in the Bogalusa study, but died by accident (so supposedly healthy) also found that those with elevated blood pressure were more likely to have atherosclerotic lesions in their aorta than those with normal blood pressure.

The researchers studied two kinds of overweight measures: body mass index (BMI), a measure of general overweight; and waist circumference, a measure of abdominal obesity. Although BMI and waist circumference were both associated with elevated blood pressure prevalence, the rise in abdominal obesity explained more of the rise in elevated blood pressure prevalence than did the rise in general obesity, Din-Dzietham said. For example, if the prevalence of obesity had not increased between 1988-1994 and 1999-2002, in 1999-2002 the prevalence of pre-HBP would have been lower by 64 percent when considering abdominal obesity and 27 percent lower when considering general obesity.

High blood pressure is a major public health problem in adults and a common risk factor for heart attack and stroke.

"This is a major public health problem," Din-Dzietham said. "Unless this upward trend in high blood pressure is reversed, we could be facing an explosion of new cardiovascular disease cases in young adults and adults. To reverse the upward trend at the beginning is good, and that's why we need to act now."

Co-authors are Yong Liu, M.S.; Marie-Vero Bielo, M.D.; and Falah Shamsa, Ph.D.

Note: This story has been adapted from a news release issued by Morehouse School Of Medicine.

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