THE COLOUR IS GRAY: As obesity goes global, researchers seek 'drug cocktail' to curb appetites

THE COLOUR IS GRAY

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The world is rapidly becoming a fatter place.

"It's a very different world than it was a while back," said Barry Popkin, director of the University of North Carolina's Interdisciplinary Obesity Center. "The bulk of the world is fat."

Even the Mediterranean diet isn't stopping Europeans' expanding waistlines. In Italy, 42 percent of adults are overweight and 9 percent are obese, according to the World Health Organization. In France, 41 percent of adults are overweight; 11 percent obese.

So what is causing the fat boom?

Some scientists blame the changes in our diet. In developing countries such as China, lower prices for cooking oil have led to more fried foods. At the same time, food prices are declining, and people around the world are picking up Americans' bad habits: consuming fast food, sodas and other high-calorie snacks and drinks.

"Frankly, it's very hard to work off a Coke," Popkin said.

While the obesity epidemic has exploded, some scientists have been frantically trying to find a drug that will curb appetites.

The answer, some say, may be a "drug cocktail," a combination of medications that doctors would prescribe before patients become obese.

If obesity trends continue, researchers at Johns Hopkins University estimate, 75 percent of American adults will be overweight or obese in just eight years, 41 percent will be obese, and nearly 25 percent of children will be overweight or obese.

While the world's girth has grown, a small community of obesity researchers has been trying to understand the complicated network of hormones that seem to trigger overeating.

"One of the problems in obesity research has been that there are so many dead ends," said Louis J. Aronne, clinical professor of medicine at Cornell University and former president of the Obesity Society, an organization of obesity researchers. "It's a very complex system with many overlapping mechanisms."

The problem, Aronne says, is like an ever-changing puzzle. Whenever scientists think they have found a drug that will block hunger or create a feeling of fullness, the body adapts - and its survival mechanism kicks in. So far, prescription diet drugs have had limited effect, enabling dieters to lose 5 percent to 10 percent of their body weight.

"You do one thing, and your body compensates for that. So that means combination therapies are going to be the way to go," Aronne said.

That's where the drug cocktail comes in.

Because obesity has been linked to 53 diseases, including diabetes, heart disease, stroke and cancer, Aronne thinks insurance companies will pay for drugs, rather than pay far more to treat the diseases that obesity causes.

"I'm not suggesting that everybody in the country should be on medication," he said. "I see it as an alternative pathway of helping people who are ill. But it's going to turn out to be a cost-effective way of managing these problems."